It got its name in the mid 16th century from a poem by a Renaissance scholar: its eponymous hero Syphilus, a shepherd, enrages the Sun God and is infected as punishment. Outside poetry, prostitution bears the brunt of the blame, though the real culprit was testosterone. Men infected prostitutes who then passed it on to the next client who gave it back to a new woman in a deadly spiral. Erring husbands gave it to wives who sometimes passed it on to children, though they might also get it from suckling infected wet-nurses.

Amid all this horror there were elements of poetic justice. In a manifestly corrupt church, the give-away “purple flowers” (as the repeated attacks were euphemistically known) that decorated the faces of priests, cardinals, even a pope, were indisputable evidence that celibacy was unenforceable. When Luther, a monk, married a nun, forcing the hand of the Catholic church to resist similar reform in itself, syphilis became one of the reasons the Catholic church is still in such trouble today.

Though there has been dispute in recent years over pre-15th-century European bones found with what resemble syphilitic symptoms, medical science is largely agreed that it was indeed a new disease brought back with the men who accompanied Columbus on his 1492 voyage to the Americas. In terms of germ warfare, it was a fitting weapon to match the devastation that measles and smallpox inflicted travelling the other way. It was not until 1905 that the cause of all this suffering was finally identified under the microscope – Treponema pallidum, a spirochete bacterium that enters the bloodstream and, if left untreated, attacks the nervous system, the heart, internal organs and the brain; and it was not until the 1940s and the arrival of penicillin that there was an effective cure.  

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